Insulin-Like Growth Factor-1 as a Vascular Protective Factor -- Conti et al. 110 (15): 2260 -- Circulation
نویسندگان
چکیده
The IGF-1 system is dynamic and complex,1,2 involving at least 6 IGF-1–binding proteins (IGFBP-1 through -6) and several binding protein–related proteases,1 including pregnancy-associated plasma protein-A (PAPP-A). The latter promotes IGF-1 bioavailability by cleaving IGFBP-4 and -5.3 Acute coronary syndromes have been associated with raised PAPP-A concentrations in blood, leading to the interpretation that PAPP-A may enhance the risk of coronary artery disease through increased IGF-1 in vascular tissues.4 Recent results, however, suggest a different relation between IGF-1 and ischemic syndromes.
منابع مشابه
Insulin-like growth factor-1 as a vascular protective factor.
Elena Conti, Cinzia Carrozza, Ettore Capoluongo, Massimo Volpe, Filippo Crea, Cecilia Zuppi Insulin-Like Growth Factor-1 as a Vascular Protective Factor Print ISSN: 0009-7322. Online ISSN: 1524-4539 Copyright © 2004 American Heart Association, Inc. All rights reserved. is published by the American Heart Association, 7272 Greenville Avenue, Dallas, TX 75231 Circulation doi: 10.1161/01.CIR.000014...
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